PRMT4 peptide, biotin
SIGMA/SRP0400 - ≥90% (HPLC)
Product Type: Chemical
| assay | ≥90% (HPLC) |
| concentration | 400 μM |
| form | aqueous solution |
| packaging | pkg of 80 nmol |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | Q86X55   |
| Application: | Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications. |
| Biochem/physiol Actions: | Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers. |
| General description: | Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2. |
| Other Notes: | 200 μL at 400 μM, or 80 nmol. Sold as 80 nmol |
| Physical form: | Supplied in a TRIS-buffered solution. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |