Sestrin 2 human
SIGMA/SRP0412 - recombinant, expressed in baculovirus infected Sf9 cells, ≥35% (SDS-PAGE)
Synonym: HI95; SES2; SEST2
Product Type: Chemical
SDS-PAGE Sestrin 2 Human : Cat. No. SRP0412: Coommassie blue-stained SDS-PAGE analysis of Sestrin2. Lanes 1. 3 μg Sestrin2. 2. Protein Marker.
| assay | ≥35% (SDS-PAGE) |
| biological source | human |
| form | aqueous solution |
| mol wt | 55 kDa |
| NCBI accession no. | NM_031459   |
| packaging | pkg of 50 μg |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P58004 |
| Application: | Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats. |
| Biochem/physiol Actions: | Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration. |
| General description: | Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥35% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |