5′-NUCLEOTIDASE/CD73, His-Tag
SIGMA/SRP0570 - recombinant, expressed in HEK 293 cells
Synonym: 5′- nucleotidase; Ecto-5′-nucleotidase
Product Type: Chemical
form | frozen liquid |
mol wt | 58.6 kDa |
recombinant | expressed in HEK 293 cells |
shipped in | dry ice |
storage temp. | −70°C |
UniProt accession no. | P21589 ![]() ![]() |
Application: | 5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay. |
Biochem/physiol Actions: | 5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer. |
General description: | 5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells. |
Physical form: | Aqueous solution |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −70°C |
UNSPSC | 12352202 |