5′-NUCLEOTIDASE/CD73, His-Tag
SIGMA/SRP0570 - recombinant, expressed in HEK 293 cells
Synonym: 5′- nucleotidase; Ecto-5′-nucleotidase
Product Type: Chemical
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| form | frozen liquid |
| mol wt | 58.6 kDa |
| recombinant | expressed in HEK 293 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P21589   |
| Application: | 5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay. |
| Biochem/physiol Actions: | 5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer. |
| General description: | 5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells. |
| Physical form: | Aqueous solution |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |