TFIID, native complex human
SIGMA/SRP2012 - ≥70% (SDS-PAGE)
Product Type: Chemical
assay | ≥70% (SDS-PAGE) |
biological source | human |
color | clear colorless |
concentration | 50 μg/mL |
form | frozen liquid |
mol wt | 750 kDa |
packaging | pkg of 2 μg |
shipped in | dry ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −70°C |
UniProt accession no. | Q6P1X5 ![]() ![]() |
Biochem/physiol Actions: | TFIID is a multiprotein complex with a molecular mass of around 750 kDa that directs pre-initiation complex assembly on both TATA box-containing and TATA-less promoters. It consists of TATA-binding protein (TBP) and a number of TBP associated factors (TAFs). TBP alone can replace TFIID in a reconstituted in vitro transcription system but only the TFIID complex can mediate transcriptional activation. TAFII250, the largest subunit of TFIID contains protein kinase and histone acetyltransferase activities linking transcriptional initiation/activation with chromatin modification. In addition, multiple serine/ threonine phosphorylations of TBP and TAFs selectively inhibit the ability of TFIID to mediate transcriptional activation. |
Physical form: | Clear and colorless frozen liquid solution |
Preparation Note: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥70% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |