PC4, wild type human
SIGMA/SRP2022 - recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym: MGC102747; P15; PC4; p14
Product Type: Chemical
assay | ≥80% (SDS-PAGE) |
biological source | human |
color | clear colorless |
concentration | 1000 μg/mL |
form | frozen liquid |
mol wt | ~14.4 kDa |
NCBI accession no. | NM_006713 ![]() ![]() |
packaging | pkg of 10 μg |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage temp. | −70°C |
UniProt accession no. | P53999 ![]() ![]() |
Biochem/physiol Actions: | It plays an important role in DNA damage repair, replication and cellular transformation. It also has a role in the organization of the chromatin. The protein has been shown to be overexpressed in astrocytoma. |
Biochem/physiol Actions: | The human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is apparently through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and regulates HSSB (RPA)-dependent SV40 DNA replication. Recent studies indicated that PC4 can be acetylated by several histone acetyltransferases. |
General description: | PC4 or SUB1 homolog is a single-stranded DNA-binding protein. It is expressed in the nucleus. The gene encoding this protein is localized on human chromosome 5p13.3. |
Physical form: | Clear and colorless frozen liquid solution |
Preparation Note: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥80% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |