BRG1-mt, K798R human
SIGMA/SRP2037 - recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
Synonym: BAF190; BRG1; FLJ39786; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2; hSNF2b
Product Type: Chemical
Immunoblotting BRG1-mt, K798R Cat. No. SRP2037: BRG1-mt, K798R was separated on SDS-PAGE using 1-3 μg protein (left); and a protein marker (right).
| assay | ≥80% (SDS-PAGE) |
| biological source | human |
| color | clear |
| colorless | |
| concentration | 300 μg/mL |
| form | frozen liquid |
| mol wt | ~185 kDa |
| NCBI accession no. | NM_003072   |
| packaging | pkg of 5 μg |
| recombinant | expressed in insect cells |
| shipped in | dry ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −70°C |
| UniProt accession no. | P51532 |
| Biochem/physiol Actions: | BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and is implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Mutation of lysine to arginine at position 798 in the DNA-dependent ATPase domain of BRG1 a) failed to restore normal growth to swi2- cells, b) reduced its ability to repress c-fos transcription, and c) reduced CIITA (class II transactivator) induction and enhanced the rate of induction of the interferon-g-responsive GBP-1 gene. |
| General description: | The SMARCA4 (SWI/SNF (SWItch/sucrose non-fermentable) related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) gene is mapped to human chromosome 19p13.2. The protein encoded by the SMARCA4 gene is an ATPases transcription activator with multisubunits (12-15). |
| Physical form: | Clear and colorless frozen liquid solution |
| Preparation Note: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |