SRC1 (627-786), biotin,His tagged human
SIGMA/SRP2064 - recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym: F-SRC-1; KAT13A; MGC129719; MGC129720; RIP160; SRC1; bHLHe42; bHLHe74
Product Type: Chemical
assay | ≥80% (SDS-PAGE) |
biological source | human |
color | clear colorless |
concentration | 400 μg/mL |
form | frozen liquid |
mol wt | ~22 kDa |
NCBI accession no. | NM_003743 |
packaging | pkg of 10 μg |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −70°C |
UniProt accession no. | Q15788 |
Biochem/physiol Actions: | Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivoator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand has been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein does not contain any tag and will be useful for assays where a native untagged protein is desired. |
Physical form: | Clear and colorless frozen liquid solution |
Preparation Note: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥80% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |