p53 (1-363) C-terminal deletion human
SIGMA/SRP2077 - recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
Synonym: FLJ92943; LFS1; P53; TRP53
Product Type: Chemical
Immunoblotting p53 (1-363) C-terminal deletion Cat. No. SRP2077: p53 (1-363) C-terminal deletion was separated on SDS-PAGE using 1-3 μg protein (left); and a protein marker (right).
| assay | ≥80% (SDS-PAGE) |
| biological source | human |
| color | clear colorless |
| concentration | 850 μg/mL |
| form | frozen liquid |
| mol wt | ~41.8 kDa |
| NCBI accession no. | NM_000546   |
| packaging | pkg of 5 μg |
| recombinant | expressed in insect cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P04637 |
| Biochem/physiol Actions: | Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function. |
| Physical form: | Clear and colorless frozen liquid solution |
| Preparation Note: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |