C-fos, proto oncogene human

SIGMA/SRP2087 - recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonym: MCM1; c-fos serum response element-binding transcription factor; serum response factor

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SRP2087-5UG	5 µg	$523.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥70% (SDS-PAGE)
biological source	human
form	frozen liquid
mol wt	~53.3 kDa
NCBI accession no.	NM_003131
packaging	pkg of 5 μg
recombinant	expressed in insect cells
shipped in	dry ice
storage condition	avoid repeated freeze/thaw cycles
storage temp.	−70°C
UniProt accession no.	P11831

Biochem/physiol Actions:	The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. AP-1 and nuclear factor B (NF B) can be specifically targeted to prevent cancer induction in mouse models. AP-1 can be produced by 18 different dimeric combinations of proteins from the Jun [c-Jun, JunB and JunD] and Fos (c-Fos, FosB, Fra-1 and Fra-2) families, including Jun homodimers and Jun-Fos heterodimers. The Jun and Fos proteins contain a basic-region leucine zipper (bZIP) domain, and are capable of binding to other bZIP proteins including those from the ATF, MAF, CNC and C/EBP (CCAAT/enhancer-binding protein) subfamilies. Jun-Jun and Jun-Fos dimers bind with highest affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE) [TGA(C/G)TCA], although many other AP-1-like sites have been reported. Binding to any of these sites can be tissue-specific, or affected by neighboring sequences, and dependent upon interactions with other transcription factors or cofactors. Jun and Fos proteins can also dimerize with other bZIP proteins, allowing them to target other DNA binding sites, such as the cAMP response element (CRE), the antioxidant response elements (ARE), and half-sites composed of half of a TRE site and half of a MAF- or CNC-binding site. In addition, AP-1 proteins can interact with other proteins, including the p65 subunit of NF-B, CBP (CRE-binding-protein-binding protein) (p300), SMAD-3 and -4, and the retinoblastoma protein (see 5 for a more complete list), further increasing the combinatorial potential of Jun and Fos proteins. AP-1 regulates a variety of cellular processes, including proliferation, differentiation and apoptosis, and contributes to both basal and stimulus-activated gene expression. It is activated by growth factors, hormones, stress, cytokines, ROS and ultraviolet radiation. Activation occurs both transcriptionally and post-translationally, and is signaled predominantly through the mitogen-activated protein kinase (MAPK) cascade. The combinatorial diversity of AP-1 proteins and other interacting factors appears to influence how specific cell types respond to a stimulus.
Physical form:	Clear and colorless frozen liquid solution
Preparation Note:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥70% (SDS-PAGE)
Storage Temp.	−70°C
UNSPSC	12352202

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