I-TAC (CXCL11) from mouse
SIGMA/SRP3214 - recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym: B-R1; CXCL11
Product Type: Chemical
| assay | ≥98% (HPLC) |
| ≥98% (SDS-PAGE) | |
| biological source | mouse |
| color | white to off-white |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin, tested |
| mol wt | 9.0 kDa |
| packaging | pkg of 20 μg |
| potency | 10.0-100.0 ng/mL |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | Q9JHH5   |
| Biochem/physiol Actions: | CXCL11 (C-X-C motif chemokine 11) is involved in the wound repair in skin cells. CXCL11’s interaction with CXCR3 (C-X-C chemokine receptor type 3) polarizes naive T cells into IL (interleukin)-10hi Tregs (regulatory T cells, Tr1) and repolarizes CXCR3+CD4+ EAE (experimental autoimmune encephalomyelitis)-associ |
| General description: | CXCL11 (C-X-C motif chemokine 11), also referred to as I-TAC (interferon-inducible T-cell α chemoattractant), is from to the CXC chemokine family and is an antagonist for CC chemokine receptor 3 (CCR3) and CCR5. CXCL11 was first identified in astrocytes via cDNA sequencing. It can be induced by IFN (interferon)-γ in different cells. CXCL11 interacts with and signals via CXCR3 (C-X-C chemokine receptor type 3). Recombinant murine I-TAC is a 9.0kDa protein containing 79 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. |
| Physical form: | Lyophilized with no additives. |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Sequence: | FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |