I-TAC (CXCL11) from mouse
SIGMA/SRP3214 - recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym: B-R1; CXCL11
Product Type: Chemical
assay | ≥98% (HPLC) |
≥98% (SDS-PAGE) | |
biological source | mouse |
color | white to off-white |
form | lyophilized |
impurities | <0.1 EU/μg endotoxin, tested |
mol wt | 9.0 kDa |
packaging | pkg of 20 μg |
potency | 10.0-100.0 ng/mL |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage temp. | −20°C |
technique(s) | cell culture | mammalian: suitable |
UniProt accession no. | Q9JHH5 ![]() ![]() |
Biochem/physiol Actions: | CXCL11 (C-X-C motif chemokine 11) is involved in the wound repair in skin cells. CXCL11’s interaction with CXCR3 (C-X-C chemokine receptor type 3) polarizes naive T cells into IL (interleukin)-10hi Tregs (regulatory T cells, Tr1) and repolarizes CXCR3+CD4+ EAE (experimental autoimmune encephalomyelitis)-associ |
General description: | CXCL11 (C-X-C motif chemokine 11), also referred to as I-TAC (interferon-inducible T-cell α chemoattractant), is from to the CXC chemokine family and is an antagonist for CC chemokine receptor 3 (CCR3) and CCR5. CXCL11 was first identified in astrocytes via cDNA sequencing. It can be induced by IFN (interferon)-γ in different cells. CXCL11 interacts with and signals via CXCR3 (C-X-C chemokine receptor type 3). Recombinant murine I-TAC is a 9.0kDa protein containing 79 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. |
Physical form: | Lyophilized with no additives. |
Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Sequence: | FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |