KC (CXCL1) from mouse
SIGMA/SRP3216 - recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym: CXCL1; GRO1; GROa; NAP-3
Product Type: Chemical
assay | ≥98% (HPLC) |
≥98% (SDS-PAGE) | |
biological source | mouse |
color | off-white to yellow |
form | lyophilized |
impurities | <0.1 EU/μg endotoxin, tested |
mol wt | 7.8 kDa |
packaging | pkg of 20 μg |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage temp. | −20°C |
technique(s) | cell culture | mammalian: suitable |
UniProt accession no. | P12850 ![]() ![]() |
Application: | C-X-C motif chemokine receptor 1 (CXCL1) from mouse has been used in transwell assay for chemotaxis. |
Biochem/physiol Actions: | All three isoforms of growth-related protein (GRO) are CXC chemokines that can signal through C-X-C motif chemokine receptors 1 or 2 (CXCR1 or 2). The GRO proteins chemoattract and activate neutrophils and basophils. It has a role in host defense against polymicrobial sepsis, upregulation of intercellular adhesion molecule 1 (ICAM-1) and migration of neutrophils. The protein also activates mitogen-activated protein kinases (MAPKs), pro-inflammatory proteins and nuclear factor-κB (NF-κB). |
General description: | C-X-C motif chemokine receptor 1 (CXCL1) is also known as keratinocyte-derived chemokine (KC). It is part of the glutamate-leucine-arginin |
Physical form: | Lyophilized with no additives. |
Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Sequence: | APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |