G-CSF human
SIGMA/SRP3263 - Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym: CSF-3; GM-CSF?; MGI-1G; pluripoietin
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| ≥98% (SDS-PAGE) | |
| biological source | human |
| color | white to off-white |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin, tested |
| mol wt | 18.7 kDa |
| packaging | pkg of 10 μg |
| potency | 10.0-25.0 ng/mL |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P09919   |
| Biochem/physiol Actions: | Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It controls the production, differentiation and function of granulocytes. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. The protein has been shown to have a role in bone repair in animal models and clinically approved for neutropenia treatment. |
| General description: | Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. Human and murine G-CSF are cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17. Recombinant human G-CSF is an 18.7kDa protein consisting of 174 amino acid residues. |
| Physical form: | Lyophilized from 5 mM Sodium Citrate, pH 4.0. |
| Preparation Note: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |