IL-1 RECEPTOR ANTAGONIST human
SIGMA/SRP3327 - Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym: ICIL-1RA; IL-1RN; IL-1Ra; IRAP
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| ≥98% (SDS-PAGE) | |
| biological source | human |
| color | white to off-white |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | 17.2 kDa |
| packaging | pkg of 100 μg |
| potency | 20-40 ng/mL |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place) |
| storage temp. | −20°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P14778   |
| Application: | Interleukin-1 receptor antagonist (IL-1RA) human has been used:• to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin • to block the IL-1β binding to its receptor • to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation |
| Biochem/physiol Actions: | Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. |
| General description: | Research area: Immunology & cytokines Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues. |
| Physical form: | Lyophilized from 20 mM Tris, pH 8.0. |
| Preparation Note: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |