BMP-14 (GDF-5/CDMP-1) human
SIGMA/SRP4580 - recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym: BMP-14/ CDMP-1; Cartilage derived morphogenetic protein-1; GDF-5; bone morphogenetic protein 14
Product Type: Chemical
TGF-beta Signaling
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
| assay | ≥98% (HPLC) |
| ≥98% (SDS-PAGE) | |
| biological source | human |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | ~27 kDa |
| NCBI accession no. | X80915   |
| packaging | pkg of 50 μg |
| potency | 0.5-4 μg ED50 |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P43026 |
| Biochem/physiol Actions: | BMP-14 (bone morphogenetic protein 14) is involved in enhancing proliferations of osteoblasts, periosteum cells and connective tissue fibroblasts. It also promotes endochondral bone growth, proper development of limb skeletons and joints, and odontogenesis. It interacts with BMP type II receptor (BMPR-II) and might be involved in bone morphogenesis. Mutations in the BMP-14 gene are associated with brachydactyly type C, intervertebral disc degeneration, acromesomelic dysplasia Grebe type and osteoarthritis. |
| General description: | The gene BMP-14 (bone morphogenetic protein 14) is mapped to human chromosome 20q11.22. It belongs to the bone morphogenetic protein family. Recombinant human BMP-14 is a 27kDa homodimeric protein consisting of two 120 amino acid polypeptide chains. |
| Physical form: | Lyophilized from 10 mM Sodium Citrate, pH 3.5. |
| Preparation Note: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
| Preparation Note: | Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC); ≥98% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |