VEGF-C human
SIGMA/SRP4633 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym: VEGFC; Vascular Endothelial Growth Factor-C
MDL Number: MFCD03458368
Product Type: Chemical
assay | ≥90% (SDS-PAGE) |
biological source | human |
form | lyophilized |
impurities | endotoxin, tested |
mol wt | 15-16 kDa |
NCBI accession no. | Q6FH59 ![]() ![]() |
packaging | pkg of 10 μg |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
Application: | VEGF-C human has been used to determine cell proliferation and survival. |
Biochem/physiol Actions: | VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia. |
General description: | The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3. |
Physical form: | Lyophilized without additives. |
Reconstitution: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
Reconstitution: | Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |