VEGF-C from mouse
SIGMA/SRP4634 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym: VEGFC; Vascular Endothelial Growth Factor-C
MDL Number: MFCD03458368
Product Type: Chemical
VEGF Pathway Research areas: Angiogenesis, Metastasis, Hypoxia, Osteogenesis, Developmental biology Disease areas: Cancer, Osteoporosis, Ischemic stroke, Inflammation, Rheumatoid Arthritis, Diabetes See also: SRP3182; SRP4363; V5765; SRP4634; SRP4364; SRP4365, SRP3184
| assay | ≥90% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | ~18.0 kDa |
| NCBI accession no. | P97953   |
| packaging | pkg of 10 μg |
| potency | >200 ng/mL ED50 |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| Biochem/physiol Actions: | VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions via the VEGF receptor-3 (VEGFR-3). Studies have shown that lymphatic endothelial cells do not form sprouting capillaries without VEGF-C. It has also been observed that this protein stimulates tumor lymphangiogenesis in xenotransplanted and transgenic mouse models of cancer. |
| General description: | VEGF-C (vascular endothelial growth factor-C) is a member of the VEGF family of structurally related proteins. The gene encoding this protein is localized on mouse chromosome 8. The product here (VEGF-C from mouse) is a 129 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. Mouse VEGF-C exhibits about 85% homology with human and 97% homology with rat VEGF-C. |
| Physical form: | Lyophilized from acetic solution with 50 μg BSA per 1 μg VEGF-C. |
| Reconstitution: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
| Reconstitution: | Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |