BMP-13 human
SIGMA/SRP4639 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: CDMP-2; Cartilage-Derived Morphogenetic Protein-2; GDF-6; bone morphogenetic protein 13
Product Type: Chemical
TGF-beta Signaling
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | ~27 kDa |
| NCBI accession no. | Q6KF10   |
| packaging | pkg of 50 μg |
| potency | 0.5-4 μg/mL ED50 (determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells.) |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| General description: | BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. These ligands mediate numerous physiological processes. BMPs initiate, promote and maintain cartilage and bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Expression of BMP-13 has been found in the hypertrophic chondrocytes of ossifying long bone centers. Recombinant human BMP-13/CDMP-2 is a 27 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids polypeptide chains. |
| Physical form: | Sterile filtered and Lyophilized without additives. |
| Preparation Note: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
| Preparation Note: | Reconstitute to 0.1-1.0 mg/mL in water containing BSA (50 μg BSA per 1 μg of protein). |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |