Gremlin 2 human
SIGMA/SRP4657 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym: BMP antagonist 2; Cysteine knot superfamily 1; DAN domain family member 3; Gremlin-2; Protein related to DAN and cerberus
Product Type: Chemical
| assay | ≥95% (HPLC) |
| ≥95% (SDS-PAGE) | |
| biological source | human |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | ~17.2 kDa |
| NCBI accession no. | Q9H772   |
| packaging | pkg of 20 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q9H772 |
| General description: | Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli. |
| Physical form: | Lyophilized with no additives. |
| Reconstitution: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
| Reconstitution: | Reconstitute to 1 mg/mL with sterilized dH2O. Pipette to dissolve the protein pellet completely. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC); ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |