PLGF-1 human
SIGMA/SRP4739 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym: PGF; PIGF; PLGF 1; Placenta Growth Factor-1
MDL Number: MFCD03458012
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| ≥95% (SDS-PAGE) | |
| biological source | human |
| form | lyophilized |
| impurities | endotoxin, tested |
| mol wt | ~29.7 kDa |
| NCBI accession no. | AAD30179   |
| packaging | pkg of 25 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P49763 |
| Biochem/physiol Actions: | PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes. |
| General description: | PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce three isoforms in humans namely, PLGF1, PLGF2 and PLGF3. Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains. |
| Physical form: | Sterile filtered and lyophilized with no additives. |
| Preparation Note: | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
| Preparation Note: | Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC); ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |