DDR1 (444-end), active, GST tagged human
SIGMA/SRP5020 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
Product Type: Chemical
SDS-PAGE DDR1 (444-end), active, GST tagged, human: Cat. No. SRP5020: Purity was determined by densitometry. Molecular weight ~77 kDa. See CofA for lot-specific data.
Specific Activity DDR1 (444-end), active, GST tagged, human: Cat. No. SRP5020: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~77 kDa |
| NCBI accession no. | NM_001954   |
| product line | PRECISIO® Kinase |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 4.25-5.75 nmol/min·mg |
| storage temp. | −70°C |
| General description: | DDR1 is a member of the subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in its extracellular domain. DDR1 is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. Expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain and DDR1 is over-expressed in fast-growing invasive tumors of the breast, ovary, esophagus, brain and lung. Collagen type I mediated stimulation of DDR1 leads to activation of matrix metalloproteinase 2 and 9 as well as increased cell invasion. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 4.25-5.75 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |