DUSP22, active, GST tagged human
SIGMA/SRP5021 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: JKAP; JSP1; VHX
Product Type: Chemical
SDS-PAGE DUSP22, active, GST tagged, human: Cat. No. SRP5021: Purity was determined by densitometry. Molecular weight ~43 kDa. See CofA for lot-specific data.
Specific Activity DUSP22, active, GST tagged, human: Cat. No. SRP5021: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~43 kDa |
| NCBI accession no. | NM_020185   |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| specific activity | 510-690 nmol/min·mg |
| storage temp. | −70°C |
| General description: | Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling. |
| Physical form: | Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 510-690 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |