PTPN12 (1-355), active, GST tagged human
SIGMA/SRP5073 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: PTPG1; tcag7.1075
Product Type: Chemical
SDS-PAGE PTPN12 (1-355), active, GST tagged, human: Cat. No. SRP5073: Purity was determined by densitometry. Molecular weight ~66 kDa. See CofA for lot-specific data.
Specific Activity PTPN12 (1-355), active, GST tagged, human: Cat. No. SRP5073: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~66 kDa |
| NCBI accession no. | NM_002835   |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| specific activity | 2520-3410 nmol/min·mg |
| storage temp. | −70°C |
| General description: | Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events. |
| Physical form: | Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 2520-3410 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |