PTPN6, active, GST tagged human
SIGMA/SRP5076 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L
Product Type: Chemical
SDS-PAGE PTPN6, active, GST tagged, human: Cat. No. SRP5076: Purity was determined by densitometry. Molecular weight ~93 kDa. See CofA for lot-specific data.
Specific Activity PTPN6, active, GST tagged, human: Cat. No. SRP5076: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~93 kDa |
| NCBI accession no. | NM_080548   |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| specific activity | 820-1110 nmol/min·mg |
| storage temp. | −70°C |
| General description: | PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. |
| Physical form: | Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 820-1110 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |