Mortalin (47-end), GST tagged human
SIGMA/SRP5102 - recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: CSA; GRP75; HSPA9; HSPA9B; MGC4500; MOT; MOT2; MTHSP75; PBP74; mot-2
CAS Number: 753517-83-8
Product Type: Chemical
SDS-PAGE Mortalin (47-end), GST tagged, human: Cat. No. SRP5102: Purity was determined by densitometry. Molecular weight ~97 kDa. See CofA for lot-specific data.
| application(s) | cell analysis |
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~97 kDa |
| NCBI accession no. | NM_004134   |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| General description: | Mortalin is a mitochondrial chaperone and a member of the heat shock protein 70 family that is constitutively expressed in cells. Mortalin plays a central role in mitochondrial biogenesis through its capacity to direct the import of nuclear-encoded proteins into the mitochondria. Mortalin plays a role in the control of cell proliferation and elevated levels of mortalin have correlated with malignant transformation and poor cancer prognosis. Mortalin can support cancer cell resistance to complement-dependent cytotoxicity. Mortalin expression was decreased in the mitochondrial fraction of neurons from the substantia nigra of Parkinson disease patients. |
| Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |