IBβ , GST tagged human
SIGMA/SRP5196 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: NFKBIB; TRIP9
Product Type: Chemical
SDS-PAGE I?Bb , GST tagged, human: Cat. No. SRP5196: Purity was determined by densitometry. Molecular weight ~56 kDa. See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~56 kDa |
| NCBI accession no. | NM_002503   |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| General description: | IκBβ is part of the NFκB complex and it inactivates NFκB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IκBβ mediated by IκB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFκB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs. The PEST domain of IkBβ can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IκBβ. IκBβ has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia. |
| Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |