PHLPP2 (766-1043), GST tagged human
SIGMA/SRP5213 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: KIAA0931; PHLPPL
CAS Number: 1190937-02-0
Product Type: Chemical
SDS-PAGE PHLPP2 (766-1043), GST tagged, human: Cat. No. SRP5213: Purity was determined by densitometry. Molecular weight ~56 kDa. See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~56 kDa |
| NCBI accession no. | NM_015020   |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| General description: | PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. |
| Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |