PAD6, GST tagged human
SIGMA/SRP5227 - recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: PADI6
Product Type: Chemical
SDS-PAGE PAD6, GST tagged, human: Cat. No. SRP5227: Purity was determined by densitometry. Molecular weight ~100 kDa. See CofA for lot-specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~100 kDa |
| NCBI accession no. | NM_207421   |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| Analysis Note: | This protein is not assayed for enzymatic activity. |
| Biochem/physiol Actions: | Peptidyl arginine deiminases (PADs) convert arginine residues to citrulline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis. PAD6 is essential for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices (CPLs). PAD6/CPL superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement. |
| General description: | Peptidyl arginine deiminase 6 (PAD6) or PADI6 is a member of the peptidylarginine deiminases. It is expressed in oocytes and preimplantation embryos. The gene encoding this protein is localized on human chromosome 1p36. |
| Physical form: | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note: | after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |