c-KIT (T670E), active, GST tagged human
SIGMA/SRP5308 - PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: CD117; PBT; SCFR
Product Type: Chemical
SDS-PAGE c-KIT (T670E), active, GST tagged, human: Cat. No. SRP5308: Purity was determined by densitometry. Molecular weight ~73 kDa. See CofA for lot specific data.
Specific Activity c-KIT (T670E), active, GST tagged, human: Cat. No. SRP5308: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot specific data.
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | ~73 kDa |
| NCBI accession no. | NM_000222   |
| product line | PRECISIO® |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 3.8-5.8 nmol/min·mg |
| storage temp. | −70°C |
| General description: | c-KIT (T670E) is the human homolog of the proto-oncogene c-kit which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT (T670E) is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT (T670E) function in hematopoiesis, melanogenesis, and gametogenesis and mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. c-KIT (T670E) signaling is involved in human skin pigmentation and that this signaling pathway is regulated by sKIT. It is also help in regulating primordial germ cell growth. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Preparation Note: | After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 3.8-5.8 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |