c-KIT (T670E), active, GST tagged human
SIGMA/SRP5308 - PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: CD117; PBT; SCFR
Product Type: Chemical
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
mol wt | ~73 kDa |
NCBI accession no. | NM_000222 ![]() ![]() |
product line | PRECISIO® |
recombinant | expressed in baculovirus infected Sf9 cells |
shipped in | dry ice |
specific activity | 3.8-5.8 nmol/min·mg |
storage temp. | −70°C |
General description: | c-KIT (T670E) is the human homolog of the proto-oncogene c-kit which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT (T670E) is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT (T670E) function in hematopoiesis, melanogenesis, and gametogenesis and mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. c-KIT (T670E) signaling is involved in human skin pigmentation and that this signaling pathway is regulated by sKIT. It is also help in regulating primordial germ cell growth. |
Legal Information: | PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC |
Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Preparation Note: | After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥70% (SDS-PAGE) |
activity | specific activity: 3.8-5.8 nmol/min·mg |
Storage Temp. | −70°C |
UNSPSC | 12352200 |