c-KIT (Y823D), active, GST tagged human
SIGMA/SRP5310 - PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: CD119; PBT; SCFR
CAS Number: 1537224-27-3
Product Type: Chemical
SDS-PAGE c-KIT (Y823D), active, GST tagged, human: Cat. No. SRP5310: Purity was determined by densitometry. Molecular weight ~73 kDa. See CofA for lot specific data.
Specific Activity c-KIT (Y823D), active, GST tagged, human: Cat. No. SRP5310: Specific Activity was determined by activity assay (see datasheet for protocol). See CofA for lot specific data.
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~73 kDa |
| NCBI accession no. | NM_000222   |
| product line | PRECISIO® |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| specific activity | 0.8-1.2 nmol/min·mg |
| storage temp. | −70°C |
| technique(s) | cell culture | stem cell: suitable |
| General description: | c-KIT (Y823D) encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2. c-KIT (Y823D) is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress. A genetic variation in c-KIT (Y823D) is associated with susceptibility to Helicobacter pylori infection. In addition, defects in c-KIT (Y823D) are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. c-KIT (Y823D is also associated with the clinical outcome of HBV infection in Chinese adults. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Preparation Note: | After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 0.8-1.2 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |