UHMK1 (KIS), GST tagged human
SIGMA/SRP5368 - recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: KIS; KIST; UHMK1
Product Type: Chemical
assay | ≥70% (SDS-PAGE) |
form | buffered aqueous glycerol solution |
mol wt | ~65 kDa |
NCBI accession no. | NM_144624 ![]() ![]() |
recombinant | expressed in baculovirus infected Sf9 cells |
shipped in | dry ice |
storage temp. | −70°C |
General description: | UHMK1(KIS) or U2AF homology motif (UHM) kinase 1 is a serine/threonine protein kinase that promotes cell cycle progression through G1 phase. UHMK1 phosphorylates the cyclin-dependent kinase inhibitor 1B (p27Kip1) and this results in its export to the nucleus where it undergoes degradation. UHMK1 is a growth factor-dependent nuclear kinase which can regulate cell cycle progression. Elevated levels of UHMK1 protein in leukemia cells has been shown to promote cell cycle progression. UHMK1 has also been shown to function in the adult nervous system where it is highly expressed and the gene has been associated with schizophrenia. |
Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Preparation Note: | After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥70% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |