Procalcitonin human
SIGMA/SRP6003 - recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Synonym: CALC1; CALCA; CGRP; Calcitonin
CAS Number: 1476823-80-9
Product Type: Chemical
| assay | ≥97% (HPLC) |
| ≥97% (SDS-PAGE) | |
| biological source | human |
| form | lyophilized |
| impurities | Endotoxin, tested |
| mol wt | 12.796 kDa |
| NCBI accession no. | P01258   |
| packaging | pkg of 10 μg |
| potency | 80 ng/mL |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Procalcitonin human has been used in in vitro vascular permeability assay. |
| Biochem/physiol Actions: | Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis. |
| General description: | The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons. |
| Physical form: | Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5. |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC); ≥97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |