NT-3 from mouse
SIGMA/SRP6007 - recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Synonym: HDNF; NGF-2; NT-3; Nerve growth factor-2; Neurotrophic factor
Product Type: Chemical
| assay | ≥97% (HPLC) |
| ≥97% (SDS-PAGE) | |
| biological source | mouse |
| form | lyophilized |
| impurities | Endotoxin, tested |
| mol wt | 13.6 kDa |
| NCBI accession no. | P20181   |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| Application: | NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples. |
| Biochem/physiol Actions: | Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis. |
| General description: | NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development. Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa. |
| Physical form: | Sterile filtered and lyophilized powder |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC); ≥97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |