LBP human
SIGMA/SRP6033 - recombinant, expressed in CHO cells, 90-95% (SDS-PAGE)
Synonym: Lipopolysaccharide-
Product Type: Chemical
| assay | 90-95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| impurities | Endotoxin, tested |
| mol wt | 58.0 kDa |
| NCBI accession no. | P18428   |
| packaging | pkg of 10 μg |
| recombinant | expressed in CHO cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| technique(s) | ELISA: suitable |
| Biochem/physiol Actions: | Lipopolysaccharide binding protein (LBP) binds at lipid A of lipopolysaccharide (LPS) with high affinity (10-9M) and reduces the cellular LPS effects at CD14+ cells (IL1β, IL6, TNF-α). It acts as opsonin for GRAM negative cells, LPS, neutrophils and granulocytes. It transfers LPS to its receptor and this leads to an active inflammatory response. LBP also binds to LPS-coated erythrocytes. The protein has a role in innate immune responses against Gram-negative bacterial infections. |
| General description: | Natural lipopolysaccharide binding protein (LBP) is a 58kDa glycoprotein produced in liver. This is a His-tagged protein. It is part of a family of lipid-binding proteins. The gene encoding this protein is localized on human chromosome 20q11.23. |
| Physical form: | Lyophilized from a concentrated protein solution (0.25 mg/ml) containing PBS, pH 7.1 |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in sterile distilled H?O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 90-95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |