Cyclophilin B human
SIGMA/SRP6066 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: CYP-S1; CYPB; PPIB; Peptidyl prolyl isomerase B; SCYLP
Product Type: Product-on-demand
assay | ≥95% (SDS-PAGE) |
biological source | human |
form | liquid |
mol wt | 21.2 kDa |
NCBI accession no. | P23284 ![]() ![]() |
packaging | pkg of 100 μg |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage temp. | −70°C |
UniProt accession no. | P23284 ![]() ![]() |
Biochem/physiol Actions: | In endoplasmic reticulum (ER), Cyclophilin B works as a chaperone for exported proteins. It also participates in the intracellular transport of collagen and proper formation of collagen fibril. Cyclophilin B can bind to the Gag protein of human immunodeficiency type 1 (HIV-1) and helps in HIV replication. It is also involved in the infection of hepatitis C virus (HCV), Japanese encephalitis virus (JEV) and human papillomavirus type 16 (HPV16). Cyclophilin B protects against ER-mediated hypoxia-induced cell death. It is overexpressed in various malignancies. |
General description: | Cyclophilin B belongs to the cyclophilin family of immunophilins. It is present in the cytoplasm, nucleus, endoplasmic reticulum (ER)/golgi and plasma membrane. The protein can also be secreted from cells. The associated gene is mapped to human chromosome 15q22. |
Other Notes: | MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEK GFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAG KDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE |
Physical form: | 1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol. |
Preparation Note: | Centrifuge the vial prior to opening. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H319 |
Precautionary statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |