BMP-2 human
SIGMA/SRP6155 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym: BMP-2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
Product Type: Product-on-demand
TGF-beta Signaling
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Immunoblotting BMP-2 Cat. No. SRP6155: SDS-PAGE of human cellexp human recombinant BMP-2.
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| mol wt | 30-38 kDa (homodimer, glycosylated) |
| NCBI accession no. | P12643   |
| packaging | pkg of 10 μg |
| potency | 20-100 ng/mL ED50 |
| recombinant | expressed in HEK 293 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions. |
| Biochem/physiol Actions: | BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. |
| General description: | BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. |
| Physical form: | Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl. |
| Preparation Note: | Centrifuge the vial prior to opening. |
| Preparation Note: | Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |