EPO human
SIGMA/SRP6158 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym: EP; EPO-alpha; Epoetin; Erythropoietin-alpha; MGC138142
CAS Number: 11096-26-7
Product Type: Product-on-demand
Immunoblotting EPO Cat. No. SRP6158: SDS-PAGE of human cellexp human recombinant EPO.
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| mol wt | 36 kDa (monomer, glycosylated) |
| NCBI accession no. | P01588   |
| packaging | pkg of 10 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01588 |
| Application: | • EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells. • In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release. • It has also been used as a component of endothelial differentiation medium. |
| Biochem/physiol Actions: | EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia. |
| General description: | The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma. |
| Physical form: | Lyophilized from a PBS solution. |
| Preparation Note: | Centrifuge the vial prior to opening. |
| Preparation Note: | Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |