IL-4 human
SIGMA/SRP6172 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym: B-cell stimulatory factor 1 (BSF-1); BCGF; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Product Type: Product-on-demand
Immunoblotting IL-4 Cat. No. SRP6172: SDS-PAGE of human cellexp human recombinant IL-4.
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized |
| mol wt | (14 and 19 kDa, monomer) |
| NCBI accession no. | P05112   |
| packaging | pkg of 10 μg |
| recombinant | expressed in HEK 293 cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell culture | mammalian: suitable |
| Biochem/physiol Actions: | Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens. |
| General description: | Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Physical form: | Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl. |
| Preparation Note: | Centrifuge the vial prior to opening. |
| Reconstitution: | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |