IL-4 human
SIGMA/SRP6172 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym: B-cell stimulatory factor 1 (BSF-1); BCGF; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Product Type: Product-on-demand
assay | ≥95% (SDS-PAGE) |
biological source | human |
form | lyophilized |
mol wt | (14 and 19 kDa, monomer) |
NCBI accession no. | P05112 ![]() ![]() |
packaging | pkg of 10 μg |
recombinant | expressed in HEK 293 cells |
shipped in | dry ice |
storage temp. | −70°C |
technique(s) | cell culture | mammalian: suitable |
Biochem/physiol Actions: | Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens. |
General description: | Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Physical form: | Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl. |
Preparation Note: | Centrifuge the vial prior to opening. |
Reconstitution: | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |