sDLL-1 human
SIGMA/SRP6212 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym: Delta-1; Delta-like protein 1
Product Type: Chemical
assay | ≥95% (SDS-PAGE) |
biological source | human |
form | lyophilized powder |
impurities | <1 EU/μg endotoxin (LAL test) |
mol wt | 57-60 kDa |
packaging | pkg of 10 μg |
pkg of 50 μg | |
recombinant | expressed in HEK 293 cells |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | O00548 ![]() ![]() |
Biochem/physiol Actions: | DLL-1 (delta-like ligand 1) functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK (natural killer) cell precursors. Upregulation of DLL-1 was observed in choriocarcinoma and hepatocellular carcinoma. |
General description: | Human sDLL-1 comprises the extracellular signaling domain of DLL-1, a member of a structurally-related family of single-pass type I transmembrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues. The DLL-1 gene is mapped to human chromosome 6q27. |
Physical form: | Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5. |
Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |