PCSK9 murine
SIGMA/SRP6286 - recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
Synonym: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; Proprotein convertase subtilisin/kexin type 9
Product Type: Chemical
assay | ≥97% (SDS-PAGE) |
biological source | mouse |
form | lyophilized powder |
impurities | <1 EU/μg endotoxin (LAL test) |
mol wt | calculated mol wt 72 kDa |
observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .) | |
observed mol wt 64 kDa | |
packaging | pkg of 20 μg |
recombinant | expressed in HEK 293 cells |
shipped in | wet ice |
storage temp. | −20°C |
tag | 6-His tagged (N-terminus) |
UniProt accession no. | Q80W65 |
General description: | Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). |
Physical form: | Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |