BMP-3b human
SIGMA/SRP6321 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: BIP; BMP-3b; BMP3B; Growth differentiation factor 10
Product Type: Chemical
TGF-beta Signaling
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Immunoblotting BMP-3b/GDF-10 Cat. No. SRP6321, 15% SDS PAGE (3 μg) of human recombinant GDF-10.
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| concentration | 1 mg/mL |
| form | liquid |
| mol wt | 12.5 kDa (111 aa, 369-478 aa) |
| packaging | pkg of 100 μg |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P55107   |
| Biochem/physiol Actions: | In rats, ectopic expression of GDF10 (growth differentiation factor 10) enhances osteoblast differentiation and also helps in bone formation. It plays a role in head formation in Xenopus embryos. After stroke, it is involved in axonal sprouting and functional recovery. The GDF10 gene is downregulated in lung cancer, mammary tumor, oral cancer and malignant mesothelioma. |
| General description: | GDF10 (growth differentiation factor 10) is a member of the bone morphogenetic protein (BMP) family and the TGF-β (transforming growth factor β) superfamily. It is expressed in femur, brain, lung, skeletal, muscle, pancreas and testis. Recombinant GDF10 protein was expressed in Escherichia coli and purified by using conventional chromatography techniques. |
| Physical form: | 1 mg/mL in 10 mM sodium citrate (pH 3.5) containing 10% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |