CD5 human
SIGMA/SRP6331 - recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym: LEU1; T-cell surface glycoprotein CD5; T1
Product Type: Chemical
Immunoblotting CD5 Cat. No. SRP6331, 15% SDS PAGE (3 μg) of human recombinant CD5.
| assay | ≥80% (SDS-PAGE) |
| biological source | human |
| concentration | 1 mg/mL |
| form | liquid |
| impurities | <1 EU/μg endotoxin (LAL test) |
| mol wt | 41 kDa (371 aa, 25-372 aa + His tag) |
| packaging | pkg of 50 μg |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P06127   |
| Biochem/physiol Actions: | CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5+ cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma). |
| General description: | CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12. Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli. |
| Physical form: | 1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |