BRD1 (556-688) his tag human
SIGMA/SRP6411 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: BR140-like protein; BRPF1; BRPF2; Bromodomain & PHD finger-containing protein 2; Bromodomain containing 1; DKFZp686F0325
Product Type: Chemical
Immunoblotting BRD1 (556-688 aa) (His-Tag) Cat. No. SRP6411, 15% SDS-PAGE (3 μg) of human recombinant BRD1.
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| concentration | 0.5 mg/mL |
| form | liquid |
| mol wt | 17.8 kDa (156 aa, 556-688 aa + His Tag) |
| packaging | pkg of 100 μg |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | O95696   |
| General description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD1 is a bromodomain containing protein that has been identified as a susceptibility gene in neurological disorders, such as schizophrenia and bipolar affective disorder. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. Recombinant human BRD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Physical form: | 0.5 mg/mL in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1mM DTT. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |