LIFR/CD118 human
SIGMA/SRP6449 - recombinant, expressed in HEK 293 cells, ≥96% (SDS-PAGE)
Synonym: Cluster of Differentiation 118; FLJ98106; FLJ99923; LIF-R; Leukemia inhibitory factor receptor; SJS2; STWS; SWS
Product Type: Chemical
Immunoblotting LIFR/CD118 Cat. No. SRP6449, SDS PAGE of human recombinant LIFR/CD118.
| assay | ≥96% (SDS-PAGE) |
| form | lyophilized |
| impurities | <1 EU/μg endotoxin (LAL test) |
| mol wt | monomer calculated mol wt 115.5 kDa (This protein is fused with the Fc region of human IgG1 at the CT.) |
| observed mol wt 135-150 kDa by SDS-PAGE (reducing) | |
| recombinant | expressed in HEK 293 cells |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P42702   |
| General description: | Leukemia inhibitory factor receptor also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. |
| Physical form: | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
| Reconstitution: | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥96% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |