VLDLR human

SIGMA/SRP6469 - recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

Synonym: CARMQ1; CHRMQ1; FLJ35024; VLDL-R; VLDLRCH; very-low-density-lipoprotein receptor

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SRP6469-10UG	10 µg	$277.00 1/EA		Add To Favorites
45-SRP6469-50UG	50 µg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Immunoblotting VLDLR Cat. No. SRP6469, SDS PAGE of human recombinant VLDLR.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (SDS-PAGE)
biological source	human
form	lyophilized
impurities	<1 EU/μg endotoxin (LAL test)
mol wt	calculated mol wt 86 kDa
	observed mol wt 150 kDa by SDS-PAGE (DTT-reduced.)
	observed mol wt 180 kDa
packaging	pkg of 10 μg
	pkg of 50 μg
recombinant	expressed in HEK 293 cells
shipped in	wet ice
storage temp.	−20°C
tag	6-His tagged (C-terminus)
UniProt accession no.	P98155

Biochem/physiol Actions:	Very-low-density-lipoprotein receptor (VLDLR) is associated with the metabolism of triglyceride rich lipoproteins (VLDL,β-migrating VLDL and intermediate-density lipoprotein) involving apoprotein-E. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. Deletion in the VLDLR gene results in cerebellar hypoplasia an autosomal recessive syndrome. VLDLR gene is significantly associated with Reelin pathway.
General description:	Very-low-density-lipoprotein receptor (VLDLR) is a 130 kDa type I transmembrane protein in the low density lipoprotein (LDL) receptor family that plays a significant role in lipid metabolism and in nervous system development and function. The VLDL receptor structure is more or less homologous to that LDL receptor, excluding the eightfold repeated ligand binding domain of VLDLR, which is sevenfold in LDLR. The protein sequence of VLDLR is mostly conserved among mammals such as rabbit, human and mouse. The gene is mapped to human chromosome 9p24.2.
Physical form:	Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution:	Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (SDS-PAGE)
Storage Temp.	−20°C
UNSPSC	12352200

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