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GFRA1/GDNFRA human

SIGMA/SRP6474 - recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym: GDNFR; GFR-ALPHA-1; RET1L; RETL1; TRNR1

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SRP6474-10UG 10 µg
$322.00
1/EA
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45-SRP6474-50UG 50 µg
$0.00
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Immunoblotting GFRA1/GDNFRA Cat. No. SRP6474, SDS PAGE of human recombinant GFRA1/GDNFRA.

 

assay ≥95% (SDS-PAGE)
biological source human
form lyophilized
impurities <1 EU/μg endotoxin (LAL test)
mol wt calculated mol wt 45.5 kDa
  observed mol wt 55-60 kDa (DTT-reduced. Asp 25 is the predicted N-terminal.)
packaging pkg of 10 and 50 μg
recombinant expressed in HEK 293 cells
shipped in wet ice
storage temp. −20°C
tag 6-His tagged (C-terminus)
UniProt accession no. P56159 
General description: GDNF family receptor α-1 (GFRA1) also known as RET ligand 1 (RETL1), TGF-β-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR α-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carcinomas.
Physical form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (SDS-PAGE)
Storage Temp. −20°C
UNSPSC 12352200

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