Notch-1 from mouse
SIGMA/SRP6503 - recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym: Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300
Product Type: Chemical
| assay | ≥95% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized |
| impurities | <0.1 EU/μg endotoxin (LAL test) |
| mol wt | calculated mol wt ~85.0 kDa (The extracellular domain of mouse Notch-1 (aa 19-488) (12 epidermal growth factor-like (EGF) repeats)) |
| packaging | pkg of 25 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q01705   |
| General description: | Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins. |
| Physical form: | Lyophilized with PBS. |
| Reconstitution: | Reconstitute with sterile water to 1 mg/mL. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |