Haptoglobin (Phenotype 2-2) from human plasma
SIGMA/SRP6508 - ≥95% (SDS-PAGE)
Synonym: Hp 2-2
Product Type: Chemical
Immunoblotting Haptoglobin(Phenotype 2-2), human Plasma Cat. No. SRP6508, 4-12% Bis-Tris-HCl NuPAGE gel of Haptoglobin(Phenotype 2-2), human Plasma. Lanes 1. Haptoglobin - 5 μg (reduced/heated) 2. Haptoglobin - 10 μg (reduced/heated) 3. Haptoglobin - 20 μg (reduced/heated) 4. LMW Standard
| assay | ≥95% (SDS-PAGE) |
| biological source | human plasma |
| form | lyophilized |
| mol wt | 170-900 kDa |
| packaging | pkg of 1 mg |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P00738   |
| Application: | Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex. |
| Biochem/physiol Actions: | Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma. |
| General description: | Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2. |
| Physical form: | Lyophilized as a salt-free solid. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |