Plasminogen from human plasma
SIGMA/SRP6518 - ≥95% (SDS-PAGE)
Synonym: PLG
Product Type: Chemical
assay | ≥95% (SDS-PAGE) |
biological source | human |
form | lyophilized |
mol wt | 90.0 – 92.0 kDa |
packaging | pkg of 1 mg |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | P00747 |
Biochem/physiol Actions: | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). |
General description: | Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains. |
Physical form: | Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |