ApoJ/Clusterin from mouse
SIGMA/SRP6523 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym: AAG4; Apolipoprotein J; CLI; CLU; KUB1; MGC24903; SGP-2; SGP2; TRPM-2; TRPM2
Product Type: Chemical
assay | ≥90% (SDS-PAGE) |
biological source | mouse |
concentration | 1 mg/mL |
form | liquid |
impurities | <1 EU/μg endotoxin (LAL test) |
mol wt | ~45 kDa (Mouse nuclear Clusterin aa 22- 448 is fused at the C-terminus to a His-tag.) |
packaging | pkg of 10 μg |
pkg of 50 μg | |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | Q06890 |
General description: | Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. |
Physical form: | 1 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |