FTO human
SIGMA/SRP6526 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym: FATSO; Fat Mass and Obesity-associated Protein
Product Type: Chemical
assay | ≥90% (SDS-PAGE) |
biological source | human |
concentration | 0.2 mg/mL |
form | liquid |
impurities | <1 EU/μg endotoxin (LAL test) |
mol wt | ~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.) |
packaging | pkg of 10 μg |
recombinant | expressed in E. coli |
shipped in | wet ice |
storage temp. | −20°C |
UniProt accession no. | Q9C0B1 |
Biochem/physiol Actions: | FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans. |
General description: | FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol. |
General description: | The fat mass and obesity-associated (FTO) gene is mapped to human chromosome 16q12.2. The encoded protein is a nuclear protein and belongs to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent |
Physical form: | 0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |